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Hey Viagra users! Do you know how your magic pill works on you? Hmmm…forgotten right! Or are you ignorant about its mechanism? Whatever, am sure about one thing you were startled after reading the title of this write-up! To understand Viagra mechanism we need to first understand how one gets a penis erection. Penile erection process is initiated with sexual excitement. The stimulation generates electrical impulses in the brain and sends it to the nerves going to the penile section. The nerve then releases nitric oxide to increase the production of cyclic GMP in muscle cells of corpus cavernosum simultaneously. Nitric oxide smoothes the muscles and increases the size of the blood vessels allowing high-speed blood flow to the penis. As a result the penis is engorged with blood making it firm and strong for penetrative sex. So what we understand from this is that the level of NO (Nitric oxide) is mainly responsible for giving a strong penile erection. Viagra does not have any direct relaxant effect on the penile section but it enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5). When sexual stimulation leads to the release of Nitric oxide, the inhibition of PDE5 by Viagra causes increased levels of cyclic guanosine monophosphate which gives muscle relaxation and blood inflow to the corpus cavernosum which ultimately helps in getting the required erections of the penis. Now, I am sure you will be able to relate the Nobel Prize winner Dr. Furchgott with Viagra and its functioning. Nitric oxide was initially known as Endothelial Derived Relaxing Factor (EDRF), ERDF was released, when patients took the nitrate-type blood pressure medicines popular in the 1970s and 1980s, and in turn it caused relaxation of the smooth muscles around the blood vessels and the arteries became larger, allowing better blood flow and a lower blood pressure. In 1986, Dr. Furchgott identified the EDRF as nitric oxide. This is where the Viagra makers got the idea of a magic pill for sex which revolutionized the whole idea of impotence. They noticed from the research that the nitrate drugs had certain side-effects on the blood vessels and the arteries; relaxing the smooth muscles around the blood vessels thereby increasing the blood flows in the human body. They related it to the erectile anatomy and discovered Sildenafil citrate, a chemical that inhibited PDE5 inhibitors which is responsible for the level of NO (nitric oxide) in the penile section. Sildenafil Citrate, under the brand name of Viagra, became the pioneer pill for the treatment of erectile dysfunction and received FDA approval on March 27, 1998, the rest is history! After all a better blood flow is the key factor behind a strong erection. So the master mind behind Viagra, in a way, remains Dr. Furchgott, the inventor of nitric oxide. Without the knowledge of the existence of nitric oxide, no one could think of inhibiting phosphodiesterase type 5 to maintain the level of NO to get penis erection. Let’s toast for the good health of Dr. Furchgott and congratulate him on winning the Nobel Prize. Without his discoveries Viagra would not have been possible and millions of men with erectile dysfunction would have continued to live hopelessly and helplessly as ‘ashamed impotents’. Thanks Dr. Furchgott for everything you have given us through your discovery! vimax penis enlargement doctor penis elargement technique real pnis enlargement penis elargement procedure natural penis enlagement penile enlargement before and after photo best enlargement exercise penis penile enlargement pic before and after
Hygiene is a cornerstone of modern civilization. We all know that people living in the period of time between the end of the Roman Empire and the beginning of the modern age were not particularly concerned with washing. Some saw washing as an unnecessary luxury, others saw it as the first step toward sinning by indulging the pleasures of flesh. Some doctors even claimed that bathing was harmful to the body or the mind. Time has passed and mankind entered a new age. Nowadays many people wash every day and don’t seem to suffer any of the side effects predicted by the doctors of less scientifically advanced times. Still, we can’t really say that everybody on earth is fully aware and practicing the strictest personal hygiene. Of course, social pressure takes care of most problems, since men and women would feel too embarrassed if they were found wanting on personal hygiene. However, while many people pay little attention to it, intimate hygiene is just as important as overall hygiene. The sex organs are more sensitive than other parts of the body and frequently engaged in intimate contact, which is why they should be as clean as possible, if not cleaner. Think about it. The last thing you want when you take a lady to bed is to discover that she’s not a hygiene fan. It’s a major turnoff and it works the same way for both partners. To clean the penis start at the tip. Pull the foreskin back as far as it would go in order to expose the entire glans. Wash both the glans and the inside of the foreskin thoroughly, but gently. This is not supposed to cause pain, so be gentle with one of the most sensitive parts of your body. At the same time make sure that the glans is perfectly clean. The space between the glans and the foreskin is where the white substance known as smegma is formed. Smegma is a mixture of dead epithelial cells shed by tissues, skin oils, moisture and bacteria. Since bacteria tend to thrive in any small place that has plenty of moisture, be sure to wash away all smegma from under the foreskin. Letting bacteria and dead tissue cells accumulate is a sure way of getting every woman’s nightmare: a smelly penis. This could easily destroy a relationship, since no woman would accept to live with a man who doesn’t know or care to keep himself clean. Going down on a man whose penis smells is simply out of the question. Intimate hygiene is also important for penis enlargement. Using an enlargement device such as a traction device or a pump on an unclean penis will simply spread bacteria all over the penis. Accumulated dirt, sweat and bacteria will certainly cause infections at one point or another in the future. Men who engage in penis enlargement exercises are also exposed to infections if they fail to maintain a high standard of intimate hygiene. That why warming up and down using hot water in the shower is recommended as a good way of preparing for a penis enlargement session and as a chance to clean the penis. Circumcised men have to be even more careful about their intimate hygiene because they lack the foreskin that protects the sensitive glans from sweat, dust and all manner of substances that should not come into contact with the penis. Some men choose circumcision precisely because they think that losing the foreskin helps keep the penis clean. However, there is an ongoing debate among experts about the hazards and benefits of circumcision. Many doctors say that removing the protective foreskin is less hygienic and exposes the glans to various bacteria that cause infections of the urinary tract. At the same time, other doctors maintain that the foreskin traps smegma and dirt and so, uncircumcised men are not spared the danger of infections. Regardless of how you feel about circumcision, one thing is perfectly clear: hygiene, and especially intimate hygiene, is of the utmost importance to you. It keeps infections away from this sensitive area and makes sure that your sexual relationships will not suffer. free penile enlargement penis enlargement information does vig rx really work top penile enlargement pills discount vig rx natural pnis enlargement and lengthening penis enlargement patch penis enhancement program enlargment free penile pills sample
More than 50 percent of diabetic men suffer from impotence, and almost all complain bitterly that it has destroyed something that is very important to them. Impotence caused by diabetes can be prevented or reversed in almost all men whose bodies can still make insulin. Diabetes causes horrendous nerve damage including blindness, deafness, burning foot syndrome, loss of feeling, loss of muscle control, pain and tingling and impotence. The penis is the only gland in the body that has its blood supply shut off all the time. Muscles surrounding the penile artery constrict the artery to prevent blood from flowing to the penis. When a man is excited, his brain sends messages along nerves that cause the nerves to secrete a chemical called nitric oxide theat relaxes the muscles around the arteries to open blood flow to the penis and the balloons in the penis fill with blood and the man has an erection. More than 90 percent of diabetics who can still make their own insulin can be controlled so that they do not suffer nerve damage. When you eat, your blood sugar level rises. If it rises too high, sugar sticks to cells and causes permanent nerve damage. Doctors can measure how much sugar is stuck on cells with a blood test called HBA1C. To get your HBA1C to a normal range below 6.1, you have to avoid foods that cause a high rise in blood sugar such as those with added sugar, those made from flour such as bakery products and pastas, and fruit juices. Most cases of nerve damage from diabetes can be reversed by good control of diabetes, but sometimes the damage is permanent. For example once person goes blind from diabetes, he will never get his vision back. However, impotence is often reversible with good control of diabetes. Men who are impotent from diabetes must be seen every month and each month, the doctor must draw a blood test called HBA1C which measures diabetic control for the last 12 weeks, or another blood test called fructosamine, which measures diabetic control over the last 2 weeks. Every time, the HBA1C is greater than 6.1, the doctor must change the patient's drugs and the patient must change his diet. All diabetics should get a blood test called C-peptide to tell if their bodies can make insulin. If their C peptide is greater than 1, they should not be placed on insulin and should be started immediately on Glucophage and Actos or Avandia. These drugs lower high blood sugar levels, never cause low blood sugar, and also lower insulin to prevent obesity and heart attacks. Only if blood sugar levels cannot be controlled by diet and these insulin-lowering drugs should doctors prescribe drugs that raise insulin. easy elargement free penis surgery way penile enlargment excercises vimax patch penis enhancement surgeries best penile enlargement surgery penile enlargement fact cheap vig rx penis elargement photo enlargment free penile pills sample
Sex is a biological process, which is provided by the nature to those species that reproduce sexually. Penis in male and vagina in female are the external sexual organs without which love making is not possible. Proper erection of penis and continuity of erection during the intercourse is essential for enjoying sex by both partners which is the mechanical aspect of the love making. Thus, sex completely can be defined as a bio-mechanical process. No species enjoys sex as frequently as human beings do. Generally, under social customs, human beings establish sexual relations with the partner to whom they love; however, exceptions also exist. Love provides you a fertile ground for love making but without fulfilling mechanical requirements it is not possible to make love. Nature has provided a man capability to erect penis when he prepares for sexual intercourse. Generally, there is no need for any external stimulation for bringing penis in erect position. This kind of non-stimulated erection is very common in early young age because responses of sex hormones are quick in that phase of life. However, a mature man may need some foreplay to bring penis in erect position. Foreplay is essential for enjoying sex with high intensity. Tricks of foreplay defers according to matrix of the society. A woman has several erogenous spots over her body; kissing and titillation on those spots can ignite her for sex. In some societies, fingering and licking in vagina are very common; licking can generate irresistible urge for penetrative sex. On other hand, women generally use her hand to erect penis and an experienced woman knows how to erect penis using her mouth and tongue. There can be a stage in life when penis doesn’t erect even after all intense foreplay. Non-erection of penis makes a man impotent. In medical terminology, non-erection of penis is known as erectile dysfunction (ED). ED generally occurs in mature age when man loses his libido but it also can occur in early young age. ED is very embarrassing for a man as a woman doesn’t want come in contact with such a man who cannot satisfy her. Though ED can occur because of psychological reasons, but in more than 90% cases its cause is physical degeneration. Levitra can help all those men who are suffering from ED. Levitra pills contain Vardenafil as its active constituent, which stimulates production of GMP. Secretion of GMP takes place to fill the blood in the capillaries of penis. This stimulation and proper flow of blood provides the penis hard and firm erection. Erection of penis provided by Levitra may stay for about 4 hours because Levitra inhibits the working of phosphodiesterase-5 (PDE-5). This is the chemical secretion, which brings back penis in relaxed position and responsible for early fall of penis. The beneficial drug Levitra may have some mild side-effects like nausea, dizziness, painful erection and chest pain. These side effects are short lived and generally disappear with continuous use of Levitra for few days. This is an oral prescription medication, which should not be used without doctor’s prescription. 4 hours long erection enables a man to quench sexual thirst of a woman many times in a single sexual encounter. Probably she desperately has been waiting for such a satisfaction for a long time. penis elargement surgery vimax penis enlargement system free penis enlagement technique pennis enlargement secret penile enlargement pills review vigrx store penis enargement information enlargment free penile pills sample
What is email marketing? Basically, in plain English, email marketing is a targeted mass mailing done via email. The purpose of email marketing could be advertising in order to recruit new clients, introducing a new set of products or services to an existing client base, keeping your clients informed by means of a newsletter, etc. All of the before mentioned activities are very legitimate business efforts, as long as you respect some unwritten rules and as long as the list of emails you use is what is called 'targeted', in other words the names came from a database generated by your marketing division and represents your existing client base, a carefully selected list of potential prospects or a list of people who opted in to receive your messages. If instead of the above you use a list that you bought (you know, "25 million guaranteed AOL email addresses for only 19.95 - plus shipping"), or are doing it without warning the people on your list, or using other shady methods, then you are considered a spammer and what you are sending is spam, bulk mail, unsolicited email, basically, the main enemy of all things virtue and life in general. Yes folks, it is that easy to be labeled as a spammer, and very hard to get out of it. Once your message is considered unsolicited, you will immediately be put on zillions of black lists, side by side with those who promise inches and inches of extra extremities and hours and hours of ecstatic pleasures (for only 3 easy payments and some handling fees). Sound pretty risky, so why bother? Obviously, opt-in email advertising is far more cost effective than direct marketing via regular mail, door-to-door sales, or telemarketing. Paper, printing, envelopes, and postage can add up quickly. Door to door sales require paying out commissions. Telemarketing results in high long distance bills, often without great results, as people become more and more blood thirsty toward the people on the other end of the so called cold call. So why not just use my personal email or my company's mail server and some mailing software? In the early days of email marketing (that is, before the art of penile enlargement was crafted), that's exactly what people did. They would gather all their emails into some primitive version of a spreadsheet, fire up some mail merging program, hook it up to their corporate mail system and voila, thousands of emails were flying away. Today, the scenario is certainly possible, but let me tell you in a simple set of scenarios what can happen: One of the many not-for-profit groups that decided to police the internet will intercept that a large number of emails were generated and sent by a server near you (yep, they can do that). In order to protect the civilized world from those who spread spam, viruses and other vermin, they will put you on a list of threats to humanity. Those other nice corporate folks who were your indented recipients, have an IT department that gets constantly yelled at by angry users who get emails with naked people. Well - Mel, their IT guy decides to put up an anti-spam system that links to that not-for-profit's database of known spammers (oh yeah, did I mention you are now a 'known spammer'?) and block your emails. Your emails might actually be blocked so well that your company will have a real trouble communicating via email and your IT folks will all go nuts and/or get fired. Basically, not so good. Other things that can happen are: you'll have to build some opt-in / opt-out system, in some states there are laws that require that you make it very easy for your audience to unsubscribe, you'll have a hard time formatting your emails in a decent, eye pleasing way, etc. Lastly, the process of sending thousands of emails and managing lists, subscribing and unsubscribing people is tedious and just plain annoying. The only way to do it is with a maximum degree of automation, or, the better solution - to outsource to a company that does it professionally. Folks, I am known for promoting the "do it in house" concept, and am not that big on outsourcing. But when it comes to mass mailing... I say stay away from it and let the professionals do what they do. If you are worried about cost, know that the fee you pay for email marketing services, will still cost less than the continued overhead and expenses of the traditional options, not to mention the great possibilities of reaching a much larger audience, much faster (practically instantly). What to look for in an email marketing company? 1. Automating Your Subscribe and Unsubscribe Requests Many email marketing companies will provide you with exact HTML code you need to paste to your site to have a subscription form on your web site. The better services also provide a link at the bottom of each email that enables subscribers to update their information or unsubscribe from a list, automating everything for you. 2. Personalization of Emails Another powerful feature of many email marketing services is the ability to use mail merge capabilities to personalize each email that you send. The better services allow to have custom fields, additional to the standard first name and last name. 3. Bounceback email handling Bouncebacks are emails that are sent to email accounts that no longer exist or are full, blocked, etc. Essentially, you'll get a response stating that your message did not make it. All email list management software programs are able to manage subscribe and unsubscribe requests and send out messages, however without integrated bounceback email handling all the non-deliverable emails will be sent back to you, a rather big nuisance if your list is large. Ideally, the email software you use will be able to manage your bouncebacks for you. Whenever a bounceback is received, the software makes a note of the address and if another bounceback is received the email address will be sent to a list of dead addresses. This remove capability is extremely important since if you continuously send out emails with many bouncebacks you may be blacklisted as a spammer. This is something you really want to avoid at all cost. 4. HTML email The ability to send out HTML emails has been around for quite some time. Most email marketing companies support the ability to send out messages that include graphics and formatted text. This is surely something you'll want to look for. However, not all of your users have the ability to view email messages in HTML format. This percentage is usually between 10-20%. Instead of seeing your aesthetically pleasing email they might see a string of meaningless code. Using most email list management programs, these 10-20% of users will open up emails from you and be very inclined to call you a spammer. To avoid this, look for companies that use multi-part MIME to send out messages. When you send an HTML email in multi-part MIME, users who do not have the ability to view HTML messages will receive the email in the usual text format. So who should you use? Do your homework, read reviews, eventually, make use of a trial account and see if it fits your needs. I currently use Intellicontact (Owned by Broadwick Corporation, a company specialized in software that improves communication efficiency for businesses) - check them out at www.bsleek.com/emailmarketing - they do everything I told you about in this article, plus more.